Pruritus is an important symptomfrequently accompanying various inflammatory skin conditions. Some recent data have indicated\nthat it may also be associated with autoimmune connective tissue diseases, including systemic sclerosis and dermatomyositis;\nhowever, studies on the prevalence and clinical characteristics of pruritus in CLE are limited.We have performed a multinational,\nprospective, cross-sectional study in order to assess the prevalence and intensity of pruritus in adult patients suffering from\nvarious subtypes of CLE. After developing a questionnaire assessing various aspects of pruritus, we have surveyed 567 patients\nwith cutaneous involvement during the course of LE regarding the presence and intensity of pruritus. Pruritus was present in 425\nof all patients (75.0%) and was most frequently reported by subjects with acute CLE (82.1%), followed by chronic CLE (78.8%),\nsubacute CLE (65.9%), and intermittent CLE (55.6%) (p<0.001). Based on the Numerical Rating Scale, the severity of itch was mild,\nmoderate, and severe in 264 (62.1%), 98 (23.1%), and 63 (14.8%) patients, respectively. The highest mean pruritus intensity was\nreported by subjects with hypertrophic LE (5.1 ± 3.0 points) followed by generalized discoid LE (3.6 ± 3.0 points), subacute CLE\n(3.0 ± 3.0 points), chilblain LE (3.0 ± 1.0 points), localized discoid LE (2.6 ± 2.0 points), intermittent CLE (2.6 ± 3.0 points), acute\nCLE (2.5 ± 1.2 points), and lupus erythematosus profundus (1.9 ± 2.7 points). In conclusion, pruritus is a frequent phenomenon\nin CLE; however, in most patients it is of mild severity. Further studies are needed to better characterize its clinical characteristics\nand influence on patientsâ?? well-being.
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